The town of St. Suzanne is being terrorized by Indian raids. The marauding natives are led by a masked spectre known as "The Wolfman". When a government agent is murdered while investigating the crisis, his brother, Allen Scott, soon discovers that the town harbors many secrets.

"From Poverty Row came a movie that, perhaps more than any other, epitomizes the dark fatalism at the heart of film noir. As he hitchhikes his way from New York to Los Angeles, a down-on-his-luck nightclub pianist (Tom Neal) finds himself with a dead body on his hands and nowhere to run--a waking nightmare that goes from bad to worse when he picks up the most vicious femme fatale in cinema history, Ann Savage's snarling, monstrously conniving drifter...